The AI Reviewer for Human Subjects Research

The AI that reviews IRB submissions.

Not a tool powered by AI. The AI itself — purpose-built on the rules, frameworks, and cross-document logic that govern human subjects research. Every regulation checked. Every gap found. In minutes.

Sponsors get speed. Boards keep judgment. Everyone gets citations.

250+ rules 9 submission types 11+ frameworks PASS / WARN / FAIL · cited
sunethix · review — MINDFUL-U (initial submission)
PARSE ANALYZE COMPOSE

PROTOCOL · §8

“Residual saliva stored at −80°C for up to 10 years for future biomarker research.”

IRB APPLICATION · §I

“Samples destroyed no later than 6 months after final assay. Banking: No.”

CONSENT FORM · §3

“Your saliva samples will be destroyed after the cortisol analysis is complete.”

 
FAIL 45 CFR 46.116(c)(7)–(9)

Three documents describe the same biospecimens three different ways. The consent form also omits all three 2018 Common Rule biospecimen elements. Reconciliation required before board review.

Illustration of an actual Sunethix finding, from a masked demo submission. No real PHI, study, or investigator.

By the numbers

Built like an engine.
Cited like a regulator.

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regulatory rules, versioned and auditable
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submission types, each with its own rule set
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federal & international frameworks
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upload to citation-backed report
How it works

An agentic pipeline, not a prompt.

Dozens of focused operations per submission. The model does the work — the system runs the loop, records every step, and keeps the audit trail.

PHASE 01 · PARSE

Parse

Reads every document — protocol, consent, HIPAA, recruitment — and extracts structure, key facts, and cross-document relationships.

PHASE 02 · ANALYZE

Analyze

Runs 250+ rules in three tiers: federal baseline, your institution's rules, and site-level overrides. Each rule fires independently — repeatable, defensible.

PHASE 03 · COMPOSE

Compose

Assembles a shareable, audit-ready report. Every PASS, WARN, and FAIL traced to its citation, page, and section.

End to end: 20–25 minutes per full review. Every finding cites the exact regulation — like 45 CFR 46.116 — the document location, and a plain-English rationale.

AUDIT TRAIL — EVERY STEP THE SYSTEM DID, WITH TIMESTAMP

14:22:01 PHASE 1 parsed protocol.pdf → 8 sections, 27 facts extracted
14:22:04 PHASE 1 re-parsed consent.pdf (retry 2/3) → table extraction resolved → clean
14:22:19 PHASE 2 rule 187/256 · FAIL · biospecimen retention conflicts across 3 documents
14:22:58 PHASE 3 report composed · 247 PASS · 8 WARN · 1 FAIL · audit packet sealed
Coverage

Every framework. One review.

Each submission type triggers its own rule set — different CFR sections, different required elements, different cross-document checks. Nine specialized engines, one review.

FDA REGULATIONS

21 CFR 50Informed Consent
21 CFR 54Financial Disclosure
21 CFR 56Institutional Review Boards
21 CFR 312IND Applications
21 CFR 812IDE Applications

HHS · COMMON RULE

45 CFR 46Common Rule (2018)
Subpart BPregnant Women & Fetuses
Subpart CPrisoners
Subpart DChildren
42 CFR Part 2SUD Records
42 CFR 50-FInvestigator COI

PRIVACY & ANTI-DISCRIMINATION

HIPAAPrivacy Rule
GINAGenetic Information

TRANSPARENCY & INTERNATIONAL

FDAAA 801ClinicalTrials.gov
ICH E6(R3)Good Clinical Practice
Initial ProtocolFULL BOARD / EXPEDITED
Protocol AmendmentEXPEDITED
Informed ConsentREQUIRED
Continuing ReviewREQUIRED
Adverse EventURGENT
Protocol DeviationEXPEDITED
Recruitment MaterialsEXPEDITED
HIPAA AuthorizationREQUIRED
Study ClosureEXPEDITED
Plus your institution's own rules. Organization requirements and site-level overrides, layered on top of the federal baseline — checked the same way, every time.
Inside the engine

250+ rules. One living system.

Every node is a versioned, auditable rule. Every connection is a cross-document check. This is what reviews your submission — drag it.

drag to rotate · lit nodes are framework anchors
Why an engine, not a prompt

One giant prompt can't do this job.

Sunethix runs dozens of focused operations per submission. The model does the work — the system runs the loops. Here's why that matters.

FAILURE MODE

Models lose focus in one giant prompt.

A 200-page submission, 30 instructions, and 250 rules in one shot: the obvious gets caught, the subtle gets missed. This is documented model behavior.

FAILURE MODE

One prompt is not repeatable.

Run the same prompt twice on the same submission and get two different lists. No audit defense. Decomposition is what makes output deterministic.

FAILURE MODE

One prompt has no audit trail.

The model knows what it said — not what it did. The orchestration layer records every step. That record is the audit packet.

The boundaries

What it deliberately won't do.

The line we hold between review and substitution.

NEVER

Generate clinical content

Never fabricates clinically sourced content from training data. If it isn't in the submitted documents, it isn't in the finding.

NEVER

Substitute HRPP judgment

Flags regulatory discrepancies and missing elements. The ethical and scientific judgment stays with your board.

NEVER

Produce ungrounded findings

Every claim points back to the document it came from. Verification is fast by design.

NEVER

Hide how it decided

Every review logs the rule version, document location, and rationale. Auditors see exactly what was checked, and when.

Sunethix is a first pass, not a final word. Approval authority, ethical judgment, and the board's mandate under 45 CFR 46 stay exactly where the regulations put them — with your HRPP.

Who it's for

Built for everyone in the research process.

IRB offices & review teams

You stay the authority.

A tireless first pass that never replaces the board. Every submission triaged in minutes — your experts spend their time where human judgment is irreplaceable.

  • Ethical and scientific judgment stays with your board
  • Your custom rules layered on the federal baseline
  • Audit-ready reports that defend every decision
Researchers & students

Submit right the first time.

Pre-check protocols and consent forms against the same regulations your IRB uses — before you submit.

  • Findings cite the exact regulation and section
  • Fewer revision cycles, faster approval
  • Sign up instantly — no setup call
CROs, sponsors & sites

Board-ready, the first time.

Every day a package sits in revision is a day of enrollment lost. Pre-screen against the same rules the IRB runs — and walk into the board meeting clean.

  • Multi-site consistency across every consent and protocol
  • Compress revision cycles before site activation
  • Predictable timelines your sponsors can plan around

Sunethix works at every point in the chain — academic institutions, CROs, pharma sponsors, sites, IRBs, independent researchers, students, and professors. When everyone reviews against the same rules, everything that reaches the board is already better.

Pricing

Two ways to start.

Individuals sign up and run their first review in minutes. Institutions get pricing built around their program.

Self-serve plans for students, independent researchers, and professors. Full rule engine, citation-backed findings, no setup call.

Monthly Annual Save 17%

Plans above are for individual use. Reviewing on behalf of an institution, CRO, or sponsor? Get institutional pricing →

Pricing built around your program — not a card on a website.

HRPPs, IRB offices, CROs, sponsors, and multi-site programs run on volume, workflows, and governance that no fixed tier fits. Tell us about your program and we'll configure both the platform and the pricing around it.

  • Custom user quotas and site configuration
  • Volume pricing for your team
  • AI reviews + workflow, configured to your needs
  • Cross-site management and custom rule authoring
  • Priority support with a dedicated account manager

Most institutional quotes go out within two business days of this form.

Get institutional pricing

Next step

See it run on one of your submissions.

Bring a real protocol and watch findings appear live, cited to the regulation and the page — twenty-five minutes, start to finish. Sponsors and CROs: bring your slowest study. IRB teams: bring your busiest week.

prefer email? info@sunethix.com · or sign in

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